Physical Incompatibility between Parenteral Cloxacillin and Vancomycin

Chemical incompatibility of parenteral drug admixtures.

Possible Incompatibility between Amino Acids and Copper in Solutions for Pediatric Parenteral Nutrition.

The nutrient formulas used for parenteral nutrition are highly complex admixtures of multiple solutions, infused by the IV route to patients who are unable to receive nutrition by mouth or by the enteral route. The administered products contain macronutrients (amino acids, dextrose, and lipids), electrolytes (sodium, potassium, calcium, phosphate, magnesium, chloride, and acetate), micronutrien...

Comparative activity of cloxacillin and vancomycin against methicillin-susceptible Staphylococcus aureus experimental endocarditis.

OBJECTIVES To compare the activity of cloxacillin and vancomycin against methicillin-susceptible Staphylococcus aureus and to determine how rapidly their bactericidal activity occurs in cardiac vegetations. METHODS In vitro and in vivo studies using an experimental model of endocarditis in rabbits. Animals were treated for 1, 2 or 3 days with cloxacillin 200 mg/kg intramuscularly three times ...

Significant Pharmacokinetic Interactions Between Quinine and Ampicillin–Cloxacillin Combination

INTRODUCTION The co-existence of malaria with bacterial infections is common in the tropics, hence the concurrent use of antimalarials and antibiotics. OBJECTIVE This study aimed to investigate the effect on pharmacokinetics and antimicrobial activity of co-administration of quinine and combined ampicillin-cloxacillin. METHODS In total, 14 healthy adults received single oral doses of ampici...

Product quality of parenteral vancomycin products in the United States.

In response to concerns raised about the quality of parenteral vancomycin products, the U.S. Food and Drug Administration (FDA) is investigating the product quality of all FDA-approved parenteral vancomycin products available in the United States. Product quality was evaluated independently at two FDA Office of Testing and Research (FDA-OTR) sites. In the next phase of the investigation, being ...